Relationships Among Serum Leptine 、Bone Turnover Markers and Bone Mineral Density (BMD) in Normal Chinese Women
Journal of Hunan Normal University(Medical Sciences) 2009-2
Abstract：Objective To study the relationships of serum leptine 、serum osteocalcin(sOC),serum crosslinked N-telopeptide of collagen type I(sNTX) and ratio of urine cross-linked N-telopeptide of collagen type I(uNTX)/creatine(Cr) and bone mineral density(BMD) in normal women aged 20-80 years old.Methods Serum leptine、sOC、sNTX and uNTX were measured using ELISA,and BMD at anteroposterior(AP) lumbar spine L1-L4 and femoral neck(FN) using DXA(QDR 4500A) in 668 normal females.Correlations of serum leptine,bone biomarkers with age and BMD were fitted in whole female population by ten kinds of regression models.Results(1) Serum leptine had positive correlations with age,weight and body mass index(BMI)(all P < 0.001).The cubic regression model was better fitted with age-and BMI-related changes of serum leptine as compared to the other regression models,and the coefficients of determination(R2)of fitting curve were 0.050 and 0.372(P < 0.001).(2)Serum leptine was positively correlated with uNTX/Cr,but no significant correlastions with sOC and sNTX.(3) After adjusted for age and BMI,no significant correlations between serum leptine and both site BMD was found,but all bone biomarkers were negatively correlated with BMD values at both sites(all P < 0.001).Conclusion Leptine may take a role in bone turnover,but it has no direct effect on BMD.
Keywords：Leptine, Osteocalcin, Serum and urinary cross-linked N-telopeptide of type I collagen, Bone mineral density, Age