Study on the Pathogenesis of Primary Osteoporosis in Female Patients Based on the Relationship Between Blood Stasis and Bone Metabolic Function
Chinese Journal of Osteoporosis 2017-1
Abstract：Objective This study is committed to discuss the correlations between blood cell parameters, blood stasis quantization score and bone metabolic markers in female patients with primary osteoporosis- kidney deficiency and blood stasis syndrome, in order to explore the possible mechanism that blood stasis lead to osteoporosis based on the correlation between blood stasis and bone metabolic function. Methods Ninety-nine patients meeting the inclusion criteria were divided into three groups according to age( group A: 55- 64y; group B: 65- 74y; group C: 75- 84y). Patient's age, height, weight and bone mineral density( BMD)were recorded. The parameters of blood cells: mean corpuscular volume( MCV), red blood cell distribution width-coefficient of variation( RDW-CV), mean platelet volume( MPV), platelet distribution width( PDW), bone metabolic markers( PINP, β-CTx) and blood stasis quantization score were tested. Pearson correlation analysis was used to evaluate the relationships between blood cell parameters, bone metabolic markers and other related factors. Results( 1) The level of MCV increased with the increase of patient's age. There was significant difference of MCV between group A and group C, P < 0. 01, and group B and group C, P < 0. 05. Blood stasis quantization score increased with the increase of patient's age. There was significant difference of blood stasis quantization score between group A and group C, P < 0. 01. BMD decreased with the increase of patient's age. There was significant difference of BMD between group A and group C, P < 0. 01, and group B and group C, P < 0. 05. ( 2) There was a mild positive correlation between blood stasis quantization score and MCV and RDW-CV( r = 0. 233, 0. 257, P < 0. 05). There was a mild negative correlation between BMD and MCV and blood stasis quantization score( r =- 0. 248, P < 0. 05; r =- 0. 344, P < 0. 01). There was a mild negative correlation between PDW and β-CTx and PINP( r =- 0. 199, r =- 0. 221; P < 0. 05). There was a very mild negative correlation between β-CTx and RDW-CV and MPV( r =- 0. 155, r =- 0. 154). There was a very mild negative correlation between PINP and MPV( r =- 0. 184). Conclusion This study showed that blood cell parameters and blood stasis quantization score gradually increased and BMD gradually reduced in female patients with primary osteoporosis with the increase in age. There was a mild negative correlation between blood cell parameters and BMD, PINP and β-CTx. It is supposed that blood stasis and abnormal blood cell parameters may cause bone microcirculation dysfunction, and as a result, bone microcirculation dysfunction led to abnormal bone metabolism, the metabolic rate of old bone resorption and newbone synthesis being slowed and bone reconstruction imbalanced, which led to osteoporosis. Our results suggested that blood stasis is a very important pathological basis of primary osteoporosis in female patients.
Keywords：Primary osteoporosis, Blood stasis, Microcirculation, Blood cell parameters, Bone metabolic makers